Mechanisms for the development of heart failure and improvement of cardiac function by angiotensin-converting enzyme inhibitors
نویسندگان
چکیده
Angiotensin-converting enzyme (ACE) inhibitors, which prevent the conversion of angiotensin I to II, are well-known for treatments cardiovascular diseases, such as heart failure, hypertension and acute coronary syndrome. Several these inhibitors including captopril, enalapril, ramipril, zofenopril imidapril attenuate vasoconstriction, cardiac hypertrophy adverse remodeling, improve clinical outcomes in patients with dysfunction decrease mortality. Extensive experimental research over past 35 years has revealed that beneficial effects ACE failure associated full or partial prevention remodeling. Since function is mainly determined by coordinated activities different subcellular organelles, sarcolemma, sarcoplasmic reticulum, mitochondria myofibrils, regulating intracellular concentration Ca2+ myocardial metabolism, there ample evidence suggest remodelling failing consequence defects. In fact, improvement been demonstrated be related attenuation abnormalities organelles Ca2+-handling, metabolic alterations, signal transduction defects gene expression changes cardiomyocytes. Various have also shown delay progression reducing formation development oxidative stress, level inflammatory cytokines occurrence These observations support view multiple mechanisms reduction inflammation Ca2+-handling
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Underutilization of angiotensin converting enzyme inhibitors among heart failure patients.
There are well-established guidelines regarding the use of Angiotensin converting enzyme inhibitors (ACEI) in the management of heart failure (HF). In-spite of that, many studies has documented underutilization of ACEI. Thus, this retrospective observational study aimed to evaluate the utilization of ACEI, to identify the pattern of ACEI use and the factors that might contribute to underutiliza...
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As a result of the increasing cost of health care and the limited resources available, it has become more difficult to allocate resources efficiently and effectively in the health care system. This environment has led to the development of pharmacoeconomic studies, which have been designed in response to the need for assessment of the economic benefits of a product prior to its acceptance in th...
متن کاملPotential angiotensin converting enzyme (ACE) inhibitors from Iranian traditional plants described by Avicenna’s Canon of Medicine
Objective: Hypertension is an important cause of cardiovascular disorders. The angiotensin converting enzyme (ACE) plays an important role in hypertension; therefore, inhibition of ACE in treatment of chronically elevated blood pressure is an important therapeutic approach. In the current review, we have p...
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ژورنال
عنوان ژورنال: Scripta medica
سال: 2022
ISSN: ['2490-3329']
DOI: https://doi.org/10.5937/scriptamed53-36256